1. When you first enter a new hotel room, put your luggage on a luggage rack or in the bathroom — an unlikely place for bed bugs to hide — while you inspect the bedding and furniture.
2. Pull back the bed sheets and blankets and check the mattress and box-spring seams for bugs, especially at the head of the bed. Adults, nymphs, and eggs are visible to the naked eye. Also keep your eyes peeled for exoskeletons (casings that the bugs leave behind when they molt) and dark, rust-colored spots. You can also lift the mattress and check underneath, too, using a flashlight if possible.
3. If there is any upholstered furniture, check that as well, especially at the seams and the head and neck area. If you see any telltale signs, tell hotel staff and ask for a new room, preferably in another part of the building.
4. Stow your suitcases, zipped closed, on a luggage rack or a hard surface for the length of your stay. You can also pack large plastic trash bags and keep your luggage in them during your time in the hotel. Try not to spread my stuff all over room.
5. When you get home, if you have any concerns that you’ve brought home a stray hitchhiker or two, tumble your travel clothes in a hot dryer for up to 30 minutes. Dryer heat will kill bed bugs, but simply washing the clothes usually won’t.
Source:
polination.blog 
A slight tweak to those hotel bedbug rules:
If you see any telltale signs, take a flamethrower and burn everything in the room. Then go home and never go out anywhere the public has touched ever again.
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